CXCR1/2 inhibition enhances pancreatic islet survival after transplantation
نویسندگان
چکیده
منابع مشابه
CXCR1/2 inhibition enhances pancreatic islet survival after transplantation.
Although long considered a promising treatment option for type 1 diabetes, pancreatic islet cell transformation has been hindered by immune system rejection of engrafted tissue. The identification of pathways that regulate post-transplant detrimental inflammatory events would improve management and outcome of transplanted patients. Here, we found that CXCR1/2 chemokine receptors and their ligan...
متن کاملPancreatic islet transplantation
BACKGROUND No formulation of exogenous insulin available to date has yet been able to mimic the physiological nictemeral rhythms of this hormone, and despite all engineering advancements, the theoretical proposal of developing a mechanical replacement for pancreatic beta cell still has not been reached. Thus, the replacement of beta cells through pancreas and pancreatic islet transplantation ar...
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Treatment for, and the prognosis of, type-1 diabetes mellitus (T1DM) has progressed dramatically during the last century, but the disease remains a major cause of morbidity and mortality. Although precise fi gures are not available, over 1 million United States citizens currently live with the disease, with approximately 30,000 new cases diagnosed in the US each year. The total number of people...
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457 ABSTRACT: Advances in pancreatic islet transplantation for the treatment of type 1 diabetes have occurred in the past decade. Successful transplantation using the Edmonton protocol has achieved glycemic stability and insulin independence in many recipients. However, the effect of islet transplantation on secondary complications of diabetes is still not clearly understood. The UBC Islet Tran...
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ژورنال
عنوان ژورنال: Journal of Clinical Investigation
سال: 2012
ISSN: 0021-9738
DOI: 10.1172/jci63089